World-renowned coverage of todays pharmacology at your fingertips Keeps you up-to-date with new information in this fast-changing field, including significantly revised coverage of CNS drugs, cognitive enhancers, anti-infectives, biologicals/biopharmaceuticals, lifestyle drugs, and more. Includes access to unique features, including more than 100 brand new chapter-specific multiple-choice questions and 6 new cases for immediate self-assessment. Features a color-coded layout for faster navigation and cross-referencing. Clarifies complex concepts with Key Points boxes, Clinical Uses boxes and full-color illustrations throughout.
Rang and Dale's Pharmacology Section 1. General principles 1. What is pharmacology? 2. How drugs act: general principles 3. How drugs act: molecular aspects 4. How drugs act: cellular aspects excitation, contraction and secretion 5. Biopharmaceuticals and gene therapy 6. Cell proliferation, apoptosis, repair and regeneration 7. Cellular mechanisms: host defence 8. Method and measurement in pharmacology 9. Absorption and distribution of drugs 10. Drug metabolism and elimination 11. Pharmacokinetics 12. Individual Variation, Pharmacogenomics and Personalised Medicine Section 2. Chemical Mediators 13. Chemical mediators and the autonomic nervous system 14. Cholinergic transmission 15. Noradrenergic transmission 16. 5-Hydroxytryptamine and the Pharmacology of Migraine 17. Purines 18. Local Hormones 1: Histamin and the Biologically Active Lipids. 19. Local Hormones 2: Peptides and Proteins 20. Cannabinoids 21. Nitric oxide and other gaseous mediators Section 3. Drugs affecting major organ systems 22. The heart 23. The vascular system 24. Atherosclerosis and lipid metabolism 25. Haemostasis and thrombosis 26. Haemopoietic system 27. Anti-inflammatory and immunosuppressant drugs 28. Skin 29. Respiratory system 30. The Kidney and urinary system 31. The Gastrointestinal tract 32. The control of blood glucose and drug treatment of diabetes mellitus 33. Obesity 34. The Pituitary and the adrenal cortex 35. Thyroid 36. The reproductive system 37. Bone metabolism Section 4. Nervous System 38. Chemical transmission and drug action in the nervous system 39. Amino acid transmitters 40. Other transmitters and modulators 41. Neurodegenerative diseases 42. General anaesthetic agents 43. Analgesic drugs 44. Local anaesthetics and other drugs affecting sodium channels 45. Anxiolytic and hypnotic drugs 46. Antiepileptic drugs 47. Antipsychotic drugs 48. Antidepressant drugs 49. CNS stimulants and psychotomimetic drugs 50. Drug addiction, dependence and abuse Section 5. Drugs used for the treatment of infections and cancer 51. Basic principles of antimicrobial chemotherapy 52. Antibacterial drugs 53. Antiviral drugs 54. Antifungal drugs 55. Antiprotozoal drugs 56. Anthelmintic drugs 57. Anti-cancer drugs Section 6. Special Topics 58. Harmful effects of drugs 59. Lifestyle drugs and drugs in sport 60. Drug discovery and development
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